Impact of Lifestyle Interventions on Cardiovascular Risk Factors in Patients with Metabolic Syndrome
DOI:
https://doi.org/10.70749/ijbr.v3i5.1266Keywords:
Metabolic Syndrome, Lifestyle Intervention, Cardiovascular Risk, Obesity, Diet, ExerciseAbstract
Introduction: Metabolic syndrome is a growing public health concern, characterized by a cluster of cardiovascular risk factors including central obesity, hypertension, dyslipidemia, and impaired glucose regulation. Lifestyle interventions have shown promise in improving these parameters. Objective: To evaluate the impact of lifestyle interventions on cardiovascular risk factors in patients diagnosed with metabolic syndrome. Materials and Method: A six-month interventional study was conducted at Department of Cardiology, Hayatabad Medical Complex Peshawar, Pakistan from July, 2024 to December, 2024. One hundred adult patients with metabolic syndrome were enrolled. Lifestyle modifications included dietary counseling, physical activity, and behavioral support. Anthropometric and biochemical parameters were assessed at baseline and after intervention. Results: Participants showed significant reductions in waist circumference, blood pressure, fasting glucose, and triglycerides, along with an increase in HDL cholesterol. By study end, 36% of patients no longer met the criteria for metabolic syndrome. Conclusion: Structured lifestyle interventions effectively reduce cardiovascular risk factors and can reverse metabolic syndrome in a significant proportion of patients.
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Marcos-Delgado, A., Hernández-Segura, N., Fernández-Villa, T., Molina, A. J., & Martín, V. (2021). The effect of lifestyle intervention on health-related quality of life in adults with metabolic syndrome: A meta-analysis. International Journal of Environmental Research and Public Health, 18(3), 887.
https://doi.org/10.3390/ijerph18030887
Rus, M., Crisan, S., Andronie-Cioara, F. L., Indries, M., Marian, P., Pobirci, O. L., & Ardelean, A. I. (2023). Prevalence and risk factors of metabolic syndrome: A prospective study on cardiovascular health. Medicina, 59(10), 1711.
https://doi.org/10.3390/medicina59101711
Liang, M., Pan, Y., Zhong, T., Zeng, Y., & Cheng, A. S. (2021). Effects of aerobic, resistance, and combined exercise on metabolic syndrome parameters and cardiovascular risk factors: A systematic review and network meta-analysis. Reviews in Cardiovascular Medicine, 22(4).
https://doi.org/10.31083/j.rcm2204156
Wagner, K., Schwingshackl, L., Draxler, A., & Franzke, B. (2021). Impact of dietary and lifestyle interventions in elderly or people diagnosed with diabetes, metabolic disorders, cardiovascular disease, cancer and micronutrient deficiency on micronuclei frequency – A systematic review and meta-analysis. Mutation Research/Reviews in Mutation Research, 787, 108367.
https://doi.org/10.1016/j.mrrev.2021.108367
Targher, G., Byrne, C. D., & Tilg, H. (2024). MASLD: A systemic metabolic disorder with cardiovascular and malignant complications. Gut, 73(4).
https://doi.org/10.1136/gutjnl-2023-330595
Stanciu, S., Rusu, E., Miricescu, D., Radu, A. C., Axinia, B., Vrabie, A. M., Ionescu, R., Jinga, M., & Sirbu, C. A. (2023). Links between metabolic syndrome and hypertension: The relationship with the current Antidiabetic drugs. Metabolites, 13(1), 87.
https://doi.org/10.3390/metabo13010087
Rosenthal, T., Touyz, R. M., & Oparil, S. (2022). Migrating populations and health: Risk factors for cardiovascular disease and metabolic syndrome. Current Hypertension Reports, 24(9), 325-340.
https://doi.org/10.1007/s11906-022-01194-5
Wu, J., Kavanaugh, A., Lebwohl, M., Gniadecki, R., & Merola, J. (2022). Psoriasis and metabolic syndrome: Implications for the management and treatment of psoriasis. Journal of the European Academy of Dermatology and Venereology, 36(6), 797-806.
https://doi.org/10.1111/jdv.18044
Ndumele, C. E., Neeland, I. J., Tuttle, K. R., Chow, S. L., Mathew, R. O., Khan, S. S., Coresh, J., Baker-Smith, C. M., Carnethon, M. R., Després, J., Ho, J. E., Joseph, J. J., Kernan, W. N., Khera, A., Kosiborod, M. N., Lekavich, C. L., Lewis, E. F., Lo, K. B., & Ozkan, B. (2023). A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-Metabolic (CKM) syndrome: A scientific statement from the American Heart Association. Circulation, 148(20), 1636-1664.
https://doi.org/10.1161/cir.0000000000001186
Cruz-Cobo, C., Bernal-Jiménez, M. Á., Vázquez-García, R., & Santi-Cano, M. J. (2022). Effectiveness of mHealth interventions in the control of lifestyle and cardiovascular risk factors in patients after a coronary event: Systematic review and meta-analysis. JMIR mHealth and uHealth, 10(12), e39593.
Rajendran, A., Minhas, A. S., Kazzi, B., Varma, B., Choi, E., Thakkar, A., & Michos, E. D. (2023). Sex-specific differences in cardiovascular risk factors and implications for cardiovascular disease prevention in women. Atherosclerosis, 384, 117269.
https://doi.org/10.1016/j.atherosclerosis.2023.117269
Sangaraju, S. L., Yepez, D., Grandes, X., Talanki Manjunatha, R., & Habib, S. (2022). Cardio-metabolic disease and polycystic ovarian syndrome (PCOS): A narrative review. Cureus.
https://doi.org/10.7759/cureus.25076
Sotos-Prieto, M., Ortolá, R., Ruiz-Canela, M., Garcia-Esquinas, E., Martínez-Gómez, D., Lopez-Garcia, E., Martínez-González, M. Á., & Rodriguez-Artalejo, F. (2021). Association between the Mediterranean lifestyle, metabolic syndrome and mortality: A whole-country cohort in Spain. Cardiovascular Diabetology, 20(1).
https://doi.org/10.1186/s12933-020-01195-1
Li, X., Zhai, Y., Zhao, J., He, H., Li, Y., Liu, Y., Feng, A., Li, L., Huang, T., Xu, A., & Lyu, J. (2021). Impact of metabolic syndrome and it's components on prognosis in patients with cardiovascular diseases: A meta-analysis. Frontiers in Cardiovascular Medicine, 8.
https://doi.org/10.3389/fcvm.2021.704145
Natesan, V., & Kim, S. (2021). Lipid metabolism, disorders and therapeutic drugs - Review. Biomolecules & Therapeutics, 29(6), 596-604.
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