Association of Disease Outcome with Diabetes in Lung Cancer Patients

Authors

  • Amina Abid Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Punjab, Pakistan.
  • Ayaz Arshad Department of Cardiology, Mujahid Heart Center, Lahore, Punjab, Pakistan.
  • Muhammad Arslan Department of Internal Medicine, Mujahid Hospital, Lahore, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i5.1256

Keywords:

Diabetes Mellitus, Lung Cancer, Mortality

Abstract

Objective: To determine the frequency of diabetes in patients with lung cancer and to compare the frequency of mortality with diabetes in lung cancer patients. Methodology: This study was descriptive case series carried out at department of Medicine, Shaukat Khanum Memorial Cancer Hospital & Research Center Lahore. The duration of the study was six months from January 2024 to June 2024. After meeting selection criteria and applying non-probability convenient sampling 100 patients were enrolled. Informed consent and demographic details were taken. From all the lung cancer patients, history of diabetes was noted. All patients were followed up in medical wards for 3 months. If patient died during treatment, then mortality was labeled as outcome. Results: The mean age of the patients was 50.78±11.57 years and 61% patients were males. Among lung cancer patients 33% were diabetics and mortality during treatment was noted in 46% patients. In diabetics, mortality during treatment was found in 18(54.5%) patients and in non-diabetics it was observed in 28(41.8%) patients (p-value=0.229). Conclusion: This study concluded that one-third of lung cancer patients had diabetes mellitus, and 46% experienced mortality during treatment. Moreover, no statistically significant association was found between the presence of diabetes mellitus and mortality during the treatment of lung cancer patients.

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References

Bade, B. C., & Dela Cruz, C. S. (2020). Lung cancer 2020: epidemiology, etiology, and prevention. Clinics in Chest Medicine, 41(1), 1-24.

https://doi.org/10.1016/j.ccm.2019.10.001

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249.

https://doi.org/10.3322/caac.21660

Khateeb, J., Fuchs, E., & Khamaisi, M. (2019). Diabetes and lung disease: An underestimated relationship. Review of Diabetic Studies, 15(1), 1-15.

https://doi.org/10.1900/rds.2019.15.1

Goto, A., Yamaji, T., Sawada, N., Momozawa, Y., Kamatani, Y., Kubo, M., Shimazu, T., Inoue, M., Noda, M., Tsugane, S., & Iwasaki, M. (2019). Diabetes and cancer risk: A mendelian randomization study. International Journal of Cancer, 146(3), 712-719.

https://doi.org/10.1002/ijc.32310

Atchison, E. A., Gridley, G., Carreon, J. D., Leitzmann, M. F., & McGlynn, K. A. (2010). Risk of cancer in a large cohort of U.S. veterans with diabetes. International Journal of Cancer, 128(3), 635-643.

https://doi.org/10.1002/ijc.25362

Morss, A. S., & Edelman, E. R. (2007). Glucose modulates basement membrane fibroblast growth factor-2 via alterations in endothelial cell permeability. Journal of Biological Chemistry, 282(19), 14635-14644.

https://doi.org/10.1074/jbc.m608565200

García-Jiménez, C., García-Martínez, J. M., Chocarro-Calvo, A., & De la Vieja, A. (2013). A new link between diabetes and cancer: Enhanced WNT/β-catenin signaling by high glucose. Journal of Molecular Endocrinology, 52(1), R51-R66.

https://doi.org/10.1530/jme-13-0152

Su, C., Chen, W., Chen, M., Shia, B., & Wu, S. (2022). Association of diabetes severity and mortality with lung squamous cell carcinoma. Cancers, 14(10), 2553.

https://doi.org/10.3390/cancers14102553

Cloete, L. (2021). Diabetes mellitus: An overview of the types, symptoms, complications and management. Nursing Standard, 37(1), 61-66.

https://doi.org/10.7748/ns.2021.e11709

Karlin, N. J., Amin, S. B., Buras, M. R., Kosiorek, H. E., Verona, P. M., & Cook, C. B. (2017). Patient outcomes from lung cancer and diabetes mellitus: A matched case–control study. Future Science OA, 4(1).

https://doi.org/10.4155/fsoa-2017-0081

Shieh, S., Probst, J. C., Sung, F., Tsai, W., Li, Y., & Chen, C. (2012). Decreased survival among lung cancer patients with Co-morbid tuberculosis and diabetes. BMC Cancer, 12(1).

https://doi.org/10.1186/1471-2407-12-174

Harding, J. L., Andes, L. J., Gregg, E. W., Cheng, Y. J., Weir, H. K., Bullard, K. M., Burrows, N. R., & Imperatore, G. (2019). Trends in cancer mortality among people with vs without diabetes in the USA, 1988–2015. Diabetologia, 63(1), 75-84.

https://doi.org/10.1007/s00125-019-04991-x

Zhu, L., Cao, H., Zhang, T., Shen, H., Dong, W., Wang, L., & Du, J. (2016). The effect of diabetes mellitus on lung cancer prognosis. Medicine, 95(17), e3528.

https://doi.org/10.1097/md.0000000000003528

Pearson-Stuttard, J., Zhou, B., Kontis, V., Bentham, J., Gunter, M. J., & Ezzati, M. (2018). Retracted: Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment. The Lancet Diabetes & Endocrinology, 6(2), 95-104.

https://doi.org/10.1016/s2213-8587(17)30366-2

Leiter, A., Charokopos, A., Bailey, S., Gallagher, E. J., Hirsch, F. R., LeRoith, D., & Wisnivesky, J. P. (2021). Assessing the association of diabetes with lung cancer risk. Translational Lung Cancer Research, 10(11), 4200-4208.

https://doi.org/10.21037/tlcr-21-601

Hidayat, K., Du, X., Chen, G., Shi, M., & Shi, B. (2016). Abdominal obesity and lung cancer risk: Systematic review and meta-analysis of prospective studies. Nutrients, 8(12), 810.

https://doi.org/10.3390/nu8120810

Ntikoudi, E., Kiagia, M., Boura, P., & Syrigos, K. (2014). Hormones of adipose tissue and their biologic role in lung cancer. Cancer Treatment Reviews, 40(1), 22-30.

https://doi.org/10.1016/j.ctrv.2013.06.005

Luo, J., Hendryx, M., Qi, L., Ho, G. Y., & Margolis, K. L. (2016). Pre-existing diabetes and lung cancer prognosis. British Journal of Cancer, 115(1), 76-79.

https://doi.org/10.1038/bjc.2016.141

Gallagher, E. J., & LeRoith, D. (2015). Obesity and diabetes: The increased risk of cancer and cancer-related mortality. Physiological Reviews, 95(3), 727-748.

https://doi.org/10.1152/physrev.00030.2014

Liao, Y., Yin, S., Chen, Z., Li, F., & Zhao, B. (2018). [Corrigendum] high glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE NOXs pathway. Molecular Medicine Reports.

https://doi.org/10.3892/mmr.2018.9555

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Jenkins, D. M., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J., Minna, J. D., … Kim, J. (2017). The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nature Communications, 8(1).

https://doi.org/10.1038/ncomms15503

Leshem, Y., Dolev, Y., & Wolf, I. (2022). Diabetes mellitus and association with outcome in pembrolizumab treated patients with non-small cell lung cancer. Journal of Clinical Oncology, 40(16_suppl), e21079-e21079.

https://doi.org/10.1200/jco.2022.40.16_suppl.e21079

Luo, J., Hendryx, M., Qi, L., Ho, G. Y., & Margolis, K. L. (2016). Pre-existing diabetes and lung cancer prognosis. British Journal of Cancer, 115(1), 76-79.

https://doi.org/10.1038/bjc.2016.141

Currie, C. J., Poole, C. D., Jenkins-Jones, S., Gale, E. A., Johnson, J. A., & Morgan, C. L. (2012). Mortality after incident cancer in people with and without type 2 diabetes. Diabetes Care, 35(2), 299-304.

https://doi.org/10.2337/dc11-1313

Dankner, R., Boffetta, P., Balicer, R. D., Boker, L. K., Sadeh, M., Berlin, A., Olmer, L., Goldfracht, M., & Freedman, L. S. (2016). Time-dependent risk of cancer after a diabetes diagnosis in a cohort of 2.3 million adults. American Journal of Epidemiology, 183(12), 1098-1106.

https://doi.org/10.1093/aje/kwv290

Hense, H., Kajüter, H., Wellmann, J., & Batzler, W. U. (2011). Cancer incidence in type 2 diabetes patients - first results from a feasibility study of the D2C cohort. Diabetology & Metabolic Syndrome, 3(1).

https://doi.org/10.1186/1758-5996-3-15

Hatlen, P., Grønberg, B. H., Langhammer, A., Carlsen, S. M., & Amundsen, T. (2011). Prolonged survival in patients with lung cancer with diabetes mellitus. Journal of Thoracic Oncology, 6(11), 1810-1817.

https://doi.org/10.1097/jto.0b013e31822a75be

Hardavella, G., Paraskevas, A., Bellou, E., Keramida, E., Bracka, I., Gkriniouk, C., Mazarakis, S., Karampinis, I., & Demertzis, P. (2022). Diabetes and lung cancer: A sweet and sour relationship. Current Respiratory Medicine Reviews, 18(4), 241-246.

https://doi.org/10.2174/1573398x17666210917100152

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Published

2025-05-14

How to Cite

Abid , A., Arshad , A., & Arslan , M. (2025). Association of Disease Outcome with Diabetes in Lung Cancer Patients. Indus Journal of Bioscience Research, 3(5), 352–356. https://doi.org/10.70749/ijbr.v3i5.1256

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