Factors Responsible for Refusal of Insulin Administration in Diabetic Patients
DOI:
https://doi.org/10.70749/ijbr.v3i6.1853Keywords:
Insulin Refusal, Diabetes Mellitus, Psychological Barriers, Social Stigma, Treatment Adherence.Abstract
Background: Despite being a core aspect of the management of diabetes, insulin therapy still continues to be refused or delayed by patients via certain perceived fears and beliefs. It is essential to understand these attitudinal barriers to facilitate improved compliance to the therapy and health status. Objective: To determine the frequency of factors leading to refusal of insulin administration in patients with diabetes. Study Design: Descriptive cross-sectional study. Duration and Place of Study: The study was conducted from April 2024 to September 2024 at the Department of Medicine, Shaikh Khalifa Bin Zayed Al Nahyan Hospital, CMH Rawalakot. Methodology: 127 diabetic patients aged between 18 and 60 years, counselled for insulin therapy but refused it or deferred it for a period of at least three months, were covered. The respondents were interviewed through a structured questionnaire, comprising demographic details, as well as various psychological, social, and practical factors associated with insulin refusal. Results: The mean age of participants was 41.30 ± 7.77 years, and the average BMI was 26.35 ± 2.90 kg/m². Most patients were male (66.9%), rural residents (54.3%), and had Type 2 diabetes (70.1%). The most commonly reported reason for insulin refusal was fear of social stigma (63%), followed by fear of pain (55.1%), cost concerns (51.2%), and interference with work and diet (50.4%). Additional notable factors included fear of hypoglycemia and dependency (both 49.6%), perceived disease progression (46.5%), feelings of self-blame (42.5%), and concerns about weight gain (40.9%). Conclusion: Our study has concluded that insulin refusal is influenced by a multifaceted interplay of social, psychological, and economic factors.
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Hossain, M. J., Al‐Mamun, M., & Islam, M. R. (2024). Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Science Reports, 7(3).
https://doi.org/10.1002/hsr2.2004
Popoviciu, M. S., Kaka, N., Sethi, Y., Patel, N., Chopra, H., & Cavalu, S. (2023). Type 1 diabetes mellitus and autoimmune diseases: A critical review of the association and the application of personalized medicine. Journal of Personalized Medicine, 13(3), 422.
https://doi.org/10.3390/jpm13030422
Galindo, R. J., Trujillo, J. M., Low Wang, C. C., & McCoy, R. G. (2023). Advances in the management of type 2 diabetes in adults. BMJ Medicine, 2(1), e000372.
https://doi.org/10.1136/bmjmed-2022-000372
McGill, J. B., Hirsch, I. B., Parkin, C. G., Aleppo, G., Levy, C. J., & Gavin, J. R. (2024). The current and future role of insulin therapy in the management of type 2 diabetes: A narrative review. Diabetes Therapy, 15(5), 1085-1098.
https://doi.org/10.1007/s13300-024-01569-8
Ehrmann, D., Kulzer, B., Wienbarg, I., Sieber, J., Weber, S., Haak, T., & Hermanns, N. (2023). Assessing barriers and adherence to insulin injection technique in people with diabetes: Development and validation of new assessment tools. Journal of Diabetes Science and Technology, 18(6), 1362-1369.
https://doi.org/10.1177/19322968231175920
Galdón Sanz-Pastor, A., Justel Enríquez, A., Sánchez Bao, A., & Ampudia-Blasco, F. J. (2024). Current barriers to initiating insulin therapy in individuals with type 2 diabetes. Frontiers in Endocrinology, 15.
https://doi.org/10.3389/fendo.2024.1366368
Macon, E. L., Devore, M. H., Lin, Y. K., Music, M. B., Wooten, M., McMullen, C. A., Woodcox, A. M., Marksbury, A. R., Beckner, Z., Patel, B. V., Schoeder, L. A., Iles, A. N., & Fisher, S. J. (2023). Current and future therapies to treat impaired awareness of hypoglycemia. Frontiers in Pharmacology, 14.
https://doi.org/10.3389/fphar.2023.1271814
Aloke, C., Egwu, C. O., Aja, P. M., Obasi, N. A., Chukwu, J., Akumadu, B. O., Ogbu, P. N., & Achilonu, I. (2022). Current advances in the management of diabetes mellitus. Biomedicines, 10(10), 2436.
https://doi.org/10.3390/biomedicines10102436
Alshehri, F. S., & Alorfi, N. M. (2023). Saudi adults’ understanding and views of weight management practices and obesity. Diabetes, Metabolic Syndrome and Obesity, 16, 3513-3531.
https://doi.org/10.2147/dmso.s433721
Liu, C., De Roza, J., Ooi, C. W., Mathew, B. K., Elya, & Tang, W. E. (2022). Impact of patients’ beliefs about insulin on acceptance and adherence to insulin therapy: A qualitative study in primary care. BMC Primary Care, 23(1).
https://doi.org/10.1186/s12875-022-01627-9
Sugai, K., Shikuma, J., Hiroike, S., Abe, H., & Suzuki, R. (2023). Successful introduction of sensor‐augmented pump therapy in a patient with diabetes and needle phobia: A case report. Journal of Diabetes Investigation, 14(11), 1318-1320.
https://doi.org/10.1111/jdi.14061
Futaisi, A. A., Alosali, M., Al-Kazrooni, A., Al-Qassabi, S., Al-Gharabi, S., Panchatcharam, S., & Al-Mahrezi, A. M. (2022). Assessing barriers to insulin therapy among Omani diabetic patients attending three main diabetes clinics in Muscat, Oman. Sultan Qaboos University Medical Journal, 22(4), 525-531.
https://doi.org/10.18295/squmj.6.2021.086
Wu, Y., Yu, Z., Yin, X., Li, Y., Jiang, Y., Liu, G., & Sun, X. (2024). Explain the behavior change and maintenance in diabetic patients using MTM-HAPA framework. Frontiers in Psychiatry, 15.
https://doi.org/10.3389/fpsyt.2024.1497872
Sińska, B. I., Kucharska, A., Panczyk, M., Matejko, B., Traczyk, I., Harton, A., & Jaworski, M. (2023). Identification of Sociodemographic and clinical factors influencing the feeling of stigmatization in people with type 1 diabetes. Healthcare, 11(15), 2185.
https://doi.org/10.3390/healthcare11152185
Morales-Brown, L. A., Perez Algorta, G., & Salifu, Y. (2024). Understanding experiences of diabetes distress: A systematic review and thematic synthesis. Journal of Diabetes Research, 2024(1).
https://doi.org/10.1155/2024/3946553
AlBurno, H., Schneider, F., De Vries, H., Al Mohannadi, D., & Mercken, L. (2022). Determinants of adherence to insulin and blood glucose monitoring among adolescents and young adults with type 1 diabetes in Qatar: A qualitative study. F1000Research, 11, 907.
https://doi.org/10.12688/f1000research.123468.1
Inbaraj, L., Raghavendran, S., & Norman, G. (2020). Reason for refusal of insulin therapy among type 2 diabetes mellitus patients in primary care clinic in Bangalore. Journal of Family Medicine and Primary Care, 9(2), 854.
https://doi.org/10.4103/jfmpc.jfmpc_973_19
Elkarim, S. A., & Abdelaziz, S. I. (2021). Barriers to Insulin Therapy in Adult Patients with Type Two Diabetes Mellitus at Family Medicine Health Centers. Int J Fam Med Prim Care, 2(6), 1054.
Simon, P. R. P., Said, S. M., Fattah, A. Z., & Shah, S. A. (2019). Risk Factors of Insulin Refusal Among Type 2 Diabetes Mellitus Patients with Poor Glycaemic Control at Tanglin Health Clinic, Kuala Lumpur. Malaysian Journal of Medicine & Health Sciences, 15(2), 84-92.
https://medic.upm.edu.my/upload/dokumen/2019060311333112_MJMHS_June_2019.pdf
Şahin, V., Yakar, B., Gömleksiz, M., Önalan, E., & Kılınç, F. (2024). Investigating the relationship between insulin treatment refusal and psychosocial factors in type 2 diabetic patients. European Journal of Therapeutics.
https://doi.org/10.58600/eurjther2145
Shah, M. K., Couper, A. L., Sandanasamy, S., & McFarlane, P. (2024). Diabetic patients' knowledge and related factors towards insulin therapy: A systematic review. Journal of Nursing Reports in Clinical Practice, 3(3), 268-278.
https://doi.org/10.32598/jnrcp.2407.1128
Wen, S., Ruan, Y., Shi, Z., Dan, S., & Zhou, L. (2024). The barriers to insulin therapy initiation in type 2 diabetes patients: A study of general practitioner perceptions in Huinan community in south Shanghai. Diabetes, Metabolic Syndrome and Obesity, 17, 393-405.
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