Investigation and Evaluation of Organic Chemistry of Alpha-Glucosidase Inhibitors for Managing Blood Sugar Levels

Syed Muazzam Ali Shah; Farzana Akram; Hajra Naeem; Rida Fatima; Muhammad Murtza; Muhammad Shakeel Aslam; Attiq Ur Rehman; Muhammad Aamir

doi:10.70749/ijbr.v3i6.1651

Authors

Syed Muazzam Ali Shah The University of Lahore, Lahore, Punjab, Pakistan.
Farzana Akram The University of Lahore, Lahore, Punjab, Pakistan.
Hajra Naeem The University of Lahore, Lahore, Punjab, Pakistan.
Rida Fatima The University of Lahore, Lahore, Punjab, Pakistan.
Muhammad Murtza The University of Lahore, Lahore, Punjab, Pakistan.
Muhammad Shakeel Aslam The University of Lahore, Lahore, Punjab, Pakistan.
Attiq Ur Rehman Nantong University, Nantong, PR Jiangsu China.
Muhammad Aamir Minhaj University, Lahore, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i6.1651

Keywords:

Chronic Metabolic Disorder, Blood Sugar Levels, Organic Chemistry, Alpha-Glucosidase Inhibitors

Abstract

Diabetes, particularly Type 2 diabetes, is a chronic metabolic disorder characterized by insulin resistance and impaired glucose metabolism. One promising approach to managing blood glucose levels in diabetic patients is the use of alpha-glucosidase inhibitors (AGIs), which work by delaying the digestion and absorption of carbohydrates in the small intestine. This research paper explores the organic chemistry behind alpha-glucosidase inhibitors, focusing on their mechanism of action, structure-activity relationship (SAR), synthetic strategies, and the development of more selective and potent compounds. Furthermore, we discuss the therapeutic potential of AGIs in managing blood sugar levels and mitigating the long-term complications of diabetes.

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