A Comprehensive Analysis of Hydrolyzed Collagen Supplementation Effects on Skin Aging and Texture and Its Potential Benefits for Osteoarthritis

Authors

  • Muhammad Ammar Khan Department of Physical Medicine and Rehabilitation, Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Punjab, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v3i5.1601

Keywords:

Hydrolyzed Collagen, Skin Aging, Elasticity, Hydration, Wrinkle Reduction, Anti-aging, Osteoarthritis, Joints

Abstract

Background: Hydrolyzed collagen supplementation has gained popularity for its potential to improve skin health and combat signs of aging. This study investigates its effects on skin elasticity, hydration, and texture over a 12-week intervention period. Objective: To evaluate the efficacy of hydrolyzed collagen supplementation in reducing visible signs of skin aging and improving overall skin health and its potential benefits for osteoarthritis. Methods: A randomized, double-blind, placebo-controlled study was conducted with 55 participants aged 25–60 years from March 2024 to September 2024. The treatment group received 10 grams of hydrolyzed collagen daily, while the placebo group received an identical placebo. Skin elasticity, wrinkle depth, and hydration were assessed using objective tools, and self-reported improvements were collected through surveys. Results: The treatment group demonstrated significant improvements, including a 23% increase in skin elasticity (p<0.01), an 18% reduction in wrinkle depth (p<0.05), and a 28% increase in skin hydration (p<0.01). Self-assessment revealed 82% of participants in the treatment group perceived noticeable improvements compared to 33% in the placebo group. Conclusion: It is concluded that hydrolyzed collagen supplementation significantly improves signs of skin aging and offers measurable relief from osteoarthritis symptoms. Its dual benefits make it a promising non-pharmacological option for individuals seeking combined dermatologic and musculoskeletal health support.

Downloads

Download data is not yet available.

References

Squire, J. M., & Parry, D. A. D. (2017). Fibrous Protein Structures: Hierarchy, History and Heroes. Sub-Cellular Biochemistry, 82, 1–33.

https://doi.org/10.1007/978-3-319-49674-0_1

Dini, I., & Laneri, S. (2019). Nutricosmetics: A brief overview. Phytotherapy Research, 33(12), 3054–3063.

https://doi.org/10.1002/ptr.6494

Miranda, R. B., Weimer, P., & Rossi, R. C. (2021). Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis. International Journal of Dermatology, 60(12).

https://doi.org/10.1111/ijd.15518

Suleria, H., Osborne, S., Masci, P., & Gobe, G. (2015). Marine-Based Nutraceuticals: An Innovative Trend in the Food and Supplement Industries. Marine Drugs, 13(10), 6336–6351.

https://doi.org/10.3390/md13106336

De Luca, C., Mikhal’chik, E. V., Suprun, M. V., Papacharalambous, M., Truhanov, A. I., & Korkina, L. G. (2016). Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant‐derived antioxidants: a single‐blind case‐control clinical study. Oxidative medicine and cellular longevity, 2016(1), 4389410.

Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis. Skin Pharmacology and Physiology, 27(3), 113–119.

https://doi.org/10.1159/000355523

Sato, K. (2017). The presence of food-derived collagen peptides in human body-structure and biological activity. Food & function, 8(12), 4325-4330.

https://pubs.rsc.org/en/content/articlelanding/2017/fo/c7fo01275f/unauth

Choi, F. D., Sung, C. T., Juhasz, M. L., & Mesinkovsk, N. A. (2019). Oral collagen supplementation: a systematic review of dermatological applications. J Drugs Dermatol, 18(1), 9-16.

https://ybyzsolutions.com/wp-content/uploads/2023/09/Collagen-Curated-Blend-and-CAT-Clincial-Study-Dossier.pdf

Koizumi, S., Inoue, N., Shimizu, M., Kwon, C., Kim, H., & Park, K. S. (2017). Effects of Dietary Supplementation with Fish Scales-Derived Collagen Peptides on Skin Parameters and Condition: A Randomized, Placebo-Controlled, Double-Blind Study. International Journal of Peptide Research and Therapeutics, 24(3), 397–402.

https://doi.org/10.1007/s10989-017-9626-0

Bolke, L., Schlippe, G., Gerß, J., & Voss, W. (2019). A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients, 11(10), 2494.

https://doi.org/10.3390/nu11102494

Sugihara, F., Inoue, N., & Wang, X. (2015). Clinical effects of ingesting collagen hydrolysate on facial skin properties. Jpn Pharmacol Ther, 43, 67-70.

https://ndlabs.com/wp-content/uploads/2023/02/Clinical-Effects-of-Ingesting-Collagen-Hydrolysate-on-Facial-Skin-Properties.pdf

Inoue, N., Sugihara, F., & Wang, X. (2016). Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. Journal of the Science of Food and Agriculture, 96(12), 4077–4081.

https://doi.org/10.1002/jsfa.7606

Nomoto, T., & Iizaka, S. (2020). Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults. Advances in Skin & Wound Care, 33(4), 186–191.

https://doi.org/10.1097/01.asw.0000655492.40898.55

Choi, S. Y., Ko, E. J., Lee, Y. H., Kim, B. G., Shin, H. J., Seo, D. B., Lee, S. J., Kim, B. J., & Kim, M. N. (2013). Effects of collagen tripeptide supplement on skin properties: A prospective, randomized, controlled study. Journal of Cosmetic and Laser Therapy, 16(3), 132–137.

https://doi.org/10.3109/14764172.2013.854119

Genovese, L., Corbo, A., & Sibilla, S. (2017). An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants. Skin pharmacology and physiology, 30(3), 146-158.

https://doi.org/10.1159/000464470

Žmitek, K., Žmitek, J., Rogl Butina, M., & Pogačnik, T. (2020). Effects of a Combination of Water-Soluble Coenzyme Q10 and Collagen on Skin Parameters and Condition: Results of a Randomised, Placebo-Controlled, Double-Blind Study. Nutrients, 12(3), 618.

https://doi.org/10.3390/nu12030618

Yoon, H.-S., Cho, H. H., Cho, S., Lee, S.-R., Shin, M.-H., & Chung, J. H. (2014). Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo. Journal of Medicinal Food, 17(7), 810–816.

https://doi.org/10.1089/jmf.2013.3060

Schwartz, S. R., Hammon, K. A., Gafner, A., Dahl, A., Guttman, N., Fong, M., & Schauss, A. G. (2019). Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial. PubMed, 25(5), 12–29.

Czajka, A., Kania, E. M., Genovese, L., Corbo, A., Merone, G., Luci, C., & Sibilla, S. (2018). Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutrition Research, 57, 97–108.

https://doi.org/10.1016/j.nutres.2018.06.001

Ito, N., Seki, S., & Ueda, F. (2018). Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial. Marine Drugs, 16(12), 482.

https://doi.org/10.3390/md16120482

Sangsuwan, W., & Asawanonda, P. (2020). Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. Journal of Dermatological Treatment, 1–6.

https://doi.org/10.1080/09546634.2020.1725412

Pratama, G. M., Hartawan, I. G. N., Indriani, I. G. A., Yusrika, M. U., Suryantari, S. A., & Sudarsa, P. S. (2020). Potency of Spirulina platensis extract as sunscreen on Ultraviolet B exposure. Journal of Medicine and Health, 2(6).

https://doi.org/10.28932/jmh.v2i6.2484

Gill, T. J. S., Ratnayanti, I. G. A. D., & Arijana, I. G. K. N. (2018). The effect of purple mangosteen (Garcinia mangostana) peel extract on collagen fiber in male Wistar rats after Ultraviolet-B (UV-B) exposure. Intisari Sains Medis, 9(3).

https://doi.org/10.15562/ism.v9i3.295

Downloads

Published

2025-05-31

How to Cite

Khan, M. A. (2025). A Comprehensive Analysis of Hydrolyzed Collagen Supplementation Effects on Skin Aging and Texture and Its Potential Benefits for Osteoarthritis. Indus Journal of Bioscience Research, 3(5), 911–916. https://doi.org/10.70749/ijbr.v3i5.1601