Melanoma/Retinoblastoma Intra-Orbital Lesions (Imaging Results Correlation with Ultrasound and Magnetic Resonance Imaging)

Authors

  • Syed Naseer Ahmed Department of Radiology, Sheikh Khalifa Bin Zayyed Hospital, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i5.1410

Keywords:

Ultrasound, CT, MRI, Ocular Lesions, Orbital Lesions

Abstract

Objective: This study aims to correlate radiological data on ultrasonography and MRI in order to identify intra-orbital lesions. Methods: In this prospective study, 58 patients were included, representing both sexes. Patients' ages ranged from two to fifty years. All patients referred from the ophthalmology department who were clinically suspected of having orbital or eye abnormalities had CT scans. Radiological data associated with MRI and ultrasound were used to evaluate outcomes among all patients. Full data analysis was carried out using SPSS 24.0. Results: Out of the total number of instances, 49 (84.5%) were determined to be non-traumatic, whereas 9 (15.5%) proved to be traumatic. The most prevalent disease among the 49 cases of non-traumatic lesions was neoplasm, followed by infective and inflammatory lesion cases. Non- traumatic lesions were most commonly retinoblastoma (17 instances, or 34.7% of the total), followed by endocrine orbitopathy and orbital cellulitis. Nine traumatic lesion cases included six fractures (66.7% of the total), two cases of presaptal soft tissue edema (22.2%), and one case of a retained foreign body (orbital or lid) (11.1%). Conclusion: Ct scans help in lesion diagnosis, surgical planning, and monitoring of eye and orbital diseases. MDCT is the gold standard for evaluating bone, detecting calcification, and determining the location, size, and shape of lesions. Orbital and ocular lesions can be evaluated with MDCT.

Downloads

Download data is not yet available.

References

Rodjan, F., De Graaf, P., Moll, A., Imhof, S., Verbeke, J., Sanchez, E., & Castelijns, J. (2010). Brain abnormalities on MR imaging in patients with retinoblastoma. American Journal of Neuroradiology, 31(8), 1385-1389.

https://doi.org/10.3174/ajnr.a2102

Kivelä, T. (1999). Trilateral retinoblastoma: A meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. Journal of Clinical Oncology, 17(6), 1829-1829.

https://doi.org/10.1200/jco.1999.17.6.1829

Wright, K. D., Qaddoumi, I., Patay, Z., Gajjar, A., Wilson, M. W., & Rodriguez‐Galindo, C. (2010). Successful treatment of early detected trilateral retinoblastoma using standard infant brain tumor therapy. Pediatric Blood & Cancer, 55(3), 570-572.

https://doi.org/10.1002/pbc.22545

Dunkel, I. J., Jubran, R. F., Gururangan, S., Chantada, G. L., Finlay, J. L., Goldman, S., Khakoo, Y., O'Brien, J. M., Orjuela, M., Rodriguez‐Galindo, C., Souweidane, M. M., & Abramson, D. H. (2009). Trilateral retinoblastoma: Potentially curable with intensive chemotherapy. Pediatric Blood & Cancer, 54(3), 384-387.

https://doi.org/10.1002/pbc.22336

Hiwatashi, A., Togao, O., Yamashita, K., Kikuchi, K., Yoshikawa, H., Obara, M., & Honda, H. (2016). 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma. The British Journal of Radiology, 89(1067), 20160074.

https://doi.org/10.1259/bjr.20160074

Hiasat, J. G., Saleh, A., Al-Hussaini, M., Al Nawaiseh, I., Mehyar, M., Qandeel, M., Mohammad, M., Deebajah, R., Sultan, I., Jaradat, I., Mansour, A., & Yousef, Y. A. (2018). The predictive value of magnetic resonance imaging of retinoblastoma for the likelihood of high-risk pathologic features. European Journal of Ophthalmology, 29(2), 262-268.

https://doi.org/10.1177/1120672118781200

Brisse, H. J., De Graaf, P., Galluzzi, P., Cosker, K., Maeder, P., Göricke, S., Rodjan, F., De Jong, M. C., Savignoni, A., Aerts, I., Desjardins, L., Moll, A. C., Hadjistilianou, T., Toti, P., Van der Valk, P., Castelijns, J. A., & Sastre-Garau, X. (2014). Assessment of early-stage optic nerve invasion in retinoblastoma using high-resolution 1.5 Tesla MRI with surface coils: A multicentre, prospective accuracy study with histopathological correlation. European Radiology, 25(5), 1443-1452.

https://doi.org/10.1007/s00330-014-3514-1

Héran, F., Bergès, O., Blustajn, J., Boucenna, M., Charbonneau, F., Koskas, P., Lafitte, F., Nau, E., Roux, P., Sadik, J., Savatovsky, J., & Williams, M. (2014). Tumor pathology of the orbit. Diagnostic and Interventional Imaging, 95(10), 933-944.

https://doi.org/10.1016/j.diii.2014.08.002

Lee, A. G., Johnson, M. C., Policeni, B. A., & Smoker, W. R. (2009). Imaging for neuro‐ophthalmic and orbital disease – a review. Clinical & Experimental Ophthalmology, 37(1), 30-53.

https://doi.org/10.1111/j.1442-9071.2008.01822.x

Rao, A. A., Naheedy, J. H., Chen, J. Y., Robbins, S. L., & Ramkumar, H. L. (2013). A clinical update and radiologic review of pediatric orbital and ocular tumors. Journal of Oncology, 2013, 1-22.

https://doi.org/10.1155/2013/975908

Abramson, D. H. (2005). Retinoblastoma in the 20th century: Past success and future challenges the Weisenfeld lecture. Investigative Opthalmology & Visual Science, 46(8), 2684.

https://doi.org/10.1167/iovs.04-1462

Echography Center, C., Byrne, S. F., Marsh, M. J., Boldt, H. C., Green, R. L., Johnson, R. N., & Wilson, D. J. (2002). Consistency of observations from echograms made centrally in the collaborative ocular melanoma study COMS report No. 13. Ophthalmic Epidemiology, 9(1), 11-27.

https://doi.org/10.1076/opep.9.1.11.1719

Collaborative Ocular Melanoma Study Group. (2008). Baseline echographic characteristics of tumors in eyes of patients enrolled in the Collaborative Ocular Melanoma Study: COMS report no. 29. Ophthalmology, 115(8), 1390-1397.

https://doi.org/10.1016/j.ophtha.2007.12.015

Zilelioğlu, G., & Gündüz, K. (1995). Ultrasonic findings in intraocular retinoblastoma and correlation with histopathologic diagnosis. International Ophthalmology, 19(2), 71-75.

https://doi.org/10.1007/bf00133175

Varoquaux, A., Rager, O., Dulguerov, P., Burkhardt, K., Ailianou, A., & Becker, M. (2015). Diffusion-weighted and PET/MR imaging after radiation therapy for malignant head and neck tumors. RadioGraphics, 35(5), 1502-1527.

https://doi.org/10.1148/rg.2015140029

Nzeh, D. A., Owoeye, J. F. A., Ademola–Popoola, D. S., & Uyanne, I. (2005). Correlations of Clinical and Ultrasound Findings in Orbito-Ocular Disease Using Non-Dedicated Scanners: Experience at Ilorin, Nigeria. Editorial Advisory Board e, 16(3), 352-357.

Mahsud, Z. S., & Bano, S. (2004). Diagnostic role of CT scan in proptosis in paediatric age group. Journal of Postgraduate Medical Institute, 18(3).

Chinda, D., Samalia, M., Abah, E., Garba, F., Rafindadi, A., & Adamu, A. (2012). A clinico-pathological study of orbito-ocular tumors at Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria: A 5-year review. Clinical Cancer Investigation Journal, 1(3), 145-147.

https://doi.org/10.4103/2278-0513.102883

Vashisht, S., Goulatia, R. K., Dayal, Y., & Bhargava, S. (1983). Impact of computrised axial tomography on orbital diagnosis. Indian Journal of Ophthalmology, 31(4), 347-352.

https://journals.lww.com/ijo/fulltext/1983/31040/impact_of_computrised_axial_tomography_on_orbital.11.aspx

Arrigg, P. G., Hedges, T. R., & Char, D. H. (1983). Computed tomography in the diagnosis of retinoblastoma. British Journal of Ophthalmology, 67(9), 588-591.

https://doi.org/10.1136/bjo.67.9.588

Asih, D., Gatot, D., & Sitorus, R. S. (2009). Computed tomography findings of retinoblastoma patients at Cipto Mangunkusumo hospital Jakarta. Medical Journal of Indonesia, 239.

https://doi.org/10.13181/mji.v18i4.366

Galluzzi, P., Cerase, A., Hadjistilianou, T., De Francesco, S., Toti, P., Vallone, I. M., Filosomi, G., Monti, L., Bracco, S., Gennari, P., Ginanneschi, C., & Venturi, C. (2003). Retinoblastoma: Abnormal Gadolinium Enhancement of Anterior Segment of Eyes at MR Imaging with Clinical and Histopathologic Correlation. Radiology, 228(3), 683–690.

https://doi.org/10.1148/radiol.2283020466

Barkhof, F., Smeets, M., van der Valk, P., Tan, K. E. W. P., Hoogenraad, F., Peeters, J., & Valk, J. (1997). MR imaging in retinoblastoma. European Radiology, 7(5), 726–731.

https://doi.org/10.1007/bf02742934

Khelfaoui, F., Validire, P., Auperin, A., Quintana, E., Michon, J., Pacquement, H., Desjardins, L., Asselain, B., Schlienger, P., Vielh, P., Dufier, J.-L., Zucker, J.-M., & Doz, F. (1996). Histopathologic risk factors in retinoblastoma: A retrospective study of 172 patients treated in a single institution. Cancer, 77(6), 1206–1213.

https://doi.org/10.1002/(sici)1097-0142(19960315)77:6%3C1206::aid-cncr30%3E3.0.co;2-3

Downloads

Published

2025-05-20

How to Cite

Ahmed, S. N. (2025). Melanoma/Retinoblastoma Intra-Orbital Lesions (Imaging Results Correlation with Ultrasound and Magnetic Resonance Imaging). Indus Journal of Bioscience Research, 3(5), 501–505. https://doi.org/10.70749/ijbr.v3i5.1410