Frequency of Urinary Tract Infection in Simple Febrile Seizures in Children Aged 6 Months to 5 Years

Authors

  • Mina Mishal Department of Pediatric Medicine Unit II, Mayo Hospital, Lahore, Punjab, Pakistan.
  • Khola Binet Mansoor Department of Pediatric Medicine Unit II, Mayo Hospital, Lahore, Punjab, Pakistan.
  • Salik Javed Department of Pediatric Medicine Unit II, Mayo Hospital, Lahore, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i5.1346

Keywords:

Febrile Seizures, Urinary Tract Infection, Escherichia Coli, Children, Pediatrics, Fever

Abstract

Background: The most common type of convulsion in young children is febrile seizures. Urinary tract infections (UTIs) may be to blame, but they may not be found without proper testing. Objective: To determine the frequency of UTIs in children aged 6 months to 5 years presenting with simple febrile seizures. Methodology: This descriptive cross-sectional study took place over six months, from September 6, 2024 to March 06, 2025, at the Mayo Hospital in Lahore, in the Department of Pediatric Medicine, Unit II. A non-probability consective sampling method was used to include 102 children between the ages of 6 months and 5 years who were having simple febrile seizures. To identify UTI, a urine complete examination (UCE) and a urine culture and sensitivity test were done. We used SPSS version 26.0 to look at the data and chi-square tests for subgroup analysis. A p-value of less than 0.05 was considered statistically significant. Results: There were 102 children, and the average age was 29.45 months with a range of 15.30 months. 56.86% were boys. It took an average of 6.78 ± 3.25 minutes for a seizure to happen, and all the children had  fever (mean: 38.85 ± 0.65°C). UTI was found in 15.69% of cases, with Escherichia coli being the most common strain (62.50%). UTI was strongly linked to younger age (6–12 months, p=0.041) and seizures lasting less than 5 minutes (p=0.048). Conclusion: A significant proportion of children with simple febrile seizures had underlying UTIs, highlighting the need for routine urine screening in such cases to prevent complications.

Downloads

Download data is not yet available.

References

Chung, S. (2014). Febrile seizures. Korean Journal of Pediatrics, 57(9), 384.

https://doi.org/10.3345/kjp.2014.57.9.384

Laino, D., Mencaroni, E., & Esposito, S. (2018). Management of pediatric febrile seizures. International Journal of Environmental Research and Public Health, 15(10), 2232.

https://doi.org/10.3390/ijerph15102232

Patterson, J. L., Carapetian, S. A., Hageman, J. R., & Kelley, K. R. (2013). Febrile seizures. Pediatric Annals, 42(12).

https://doi.org/10.3928/00904481-20131122-09

Mosili, P., Maikoo, S., Mabandla, M. V., & Qulu, L. (2020). The pathogenesis of fever-induced febrile seizures and its current state. Neuroscience Insights, 15.

https://doi.org/10.1177/2633105520956973

Francis, J. R., Richmond, P., Robins, C., Lindsay, K., Levy, A., Effler, P. V., Borland, M., & Blyth, C. C. (2016). An observational study of febrile seizures: The importance of viral infection and immunization. BMC Pediatrics, 16(1).

https://doi.org/10.1186/s12887-016-0740-5

Roberts, K. B. (2011). Urinary tract infection: Clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics, 128(3), 595-610.

https://doi.org/10.1542/peds.2011-1330

Santen, S. A., & Altieri, M. F. (2001). Pediatric urinary tract infection. Emergency Medicine Clinics of North America, 19(3), 675-690.

https://doi.org/10.1016/s0733-8627(05)70209-1

Leung, A. K., Hon, K. L., & Leung, T. N. (2018). Febrile seizures: An overview. Drugs in Context, 7, 1-12.

https://doi.org/10.7573/dic.212536

Yang, E. M., Lee, S., & Kim, Y. O. (2024). Frequency and characteristics of seizures precipitated by febrile urinary tract infections in neonates and infants. Pediatrics & Neonatology.

https://doi.org/10.1016/j.pedneo.2024.05.004

Roupakias, S., Sinopidis, X., Karatza, A., & Varvarigou, A. (2013). Predictive risk factors in childhood urinary tract infection, Vesicoureteral reflux, and renal scarring management. Clinical Pediatrics, 53(12), 1119-1133.

https://doi.org/10.1177/0009922813515744

Mattoo, T. K., Shaikh, N., & Nelson, C. P. (2021). Contemporary management of urinary tract infection in children. Pediatrics, 147(2).

https://doi.org/10.1542/peds.2020-012138

Kazeminezhad, B., Taghinejad, H., Borji, M., & Seymohammadi, R. (2018). Evaluation of the prevalence of urinary tract infection in children with febrile seizure. Journal of Comprehensive Pediatrics, In Press(In Press).

https://doi.org/10.5812/compreped.62557

Simões E Silva, A. C., Oliveira, E. A., & Mak, R. H. (2020). Urinary tract infection in pediatrics: An overview. Jornal de Pediatria, 96(1), 65–79.

https://doi.org/10.1016/j.jped.2019.10.006 .

Costea, R. M., Maniu, I., Dobrota, L., Pérez-Elvira, R., Agudo, M., Oltra-Cucarella, J., Dragomir, A., Bacilă, C., Banciu, A., Banciu, D. D., Cipăian, C. R., Crișan, R., & Neamtu, B. (2021). Exploring inflammatory status in febrile seizures associated with urinary tract infections: A two-step cluster approach. Brain Sciences, 11(9), 1168.

https://doi.org/10.3390/brainsci11091168

Ismail, M., Nigar, I. Z., Dola, F. N., Shamsad, I. A., & Liza, N. A. (2023). Infections associated with febrile seizure in children in a tertiary care hospital. Scholars Journal of Applied Medical Sciences, 11(06), 1095-1102.

https://doi.org/10.36347/sjams.2023.v11i06.019

Naseri, M., Bakhtiari, E., & Tafazoli, N. (2019). An observational epidemiological study of febrile convulsion due to urinary tract infection. Journal of Nephropathology, 9(2), e16-e16.

https://doi.org/10.34172/jnp.2020.16

Mahyar, A, Ayazi, P, Azimi, E, Dalirani, R, Barikani, A, & Esmaeily, S. (2018). The Relation between Urinary Tract Infection and Febrile Seizure. Iran J Child Neurol. 12(4), 120-126.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6160625/pdf/ijcn-12-120.pdf

Mohhamadi, M. H., Lashgari Kalat, H., Mohammadi, M., & Mirshekari, A. (2023). Overview of Febrile Seizures in Iranian Children and Related Factors: A 30-Year Review. Health Providers, 3(2), 99-109.

https://doi.org/10.22034/hp.2024.485559.1048

Downloads

Published

2025-05-15

How to Cite

Mishal, M., Mansoor, K. B., & Javed, S. (2025). Frequency of Urinary Tract Infection in Simple Febrile Seizures in Children Aged 6 Months to 5 Years. Indus Journal of Bioscience Research, 3(5), 363–367. https://doi.org/10.70749/ijbr.v3i5.1346