Fetomaternal Outcome of Pregnancy in Women with Gestational Diabetes Mellitus
DOI:
https://doi.org/10.70749/ijbr.v3i5.1195Keywords:
Gestational Diabetes Mellitus, Fetomaternal Outcome, Glycemic Control, Pregnancy Complications, Neonatal Hypoglycemia, Congenital AnomaliesAbstract
Introduction: Gestational diabetes mellitus (GDM) is associated with increased maternal and fetal complications. This study aimed to evaluate the fetomaternal outcomes in women with GDM, considering glycemic control as a key factor. Methodology: A case series at Gulab Devi Hospital's Obstetrics and Gynecology Department in Lahore for six months involved 82 pregnant women with GDM, selected through non-probability consecutive sampling. Maternal and fetal outcomes, including pre-eclampsia, cesarean delivery, preterm birth, and neonatal hypoglycemia, were documented. Research utilized SPSS version 20 for data analysis, with Chi-square tests to determine associations (p≤0.05 significance threshold). Results: Among the participants, pre-eclampsia occurred in 24.4%, polyhydramnios in 47.6%, cesarean delivery in 68.3%, and postpartum hemorrhage in 6.1%. Preterm birth was noted in 22.0%, neonatal hypoglycemia in 20.7%, macrosomia in 14.6%, and NICU admission in 40.2%. Conclusion: GDM is linked to high rates of maternal and fetal complications, with neonatal hypoglycemia and congenital anomalies significantly associated with poor glycemic control. Strict monitoring and management of blood glucose levels are essential to improving pregnancy outcomes.
Downloads
References
Bahl, S., Dhabhai, N., Taneja, S., Mittal, P., Dewan, R., Kaur, J., Chaudhary, R., Bhandari, N., & Chowdhury, R. (2022). Burden, risk factors and outcomes associated with gestational diabetes in a population-based cohort of pregnant women from North India. BMC Pregnancy and Childbirth, 22(1).
https://doi.org/10.1186/s12884-022-04389-5
Jiwani, A., Marseille, E., Lohse, N., Damm, P., Hod, M., & Kahn, J. G. (2011). Gestational diabetes mellitus: Results from a survey of country prevalence and practices. The Journal of Maternal-Fetal & Neonatal Medicine, 25(6), 600-610.
https://doi.org/10.3109/14767058.2011.587921
Riaz, M., Nawaz, A., Masood, S. N., Fawwad, A., Basit, A., & Shera, A. (2019). Frequency of gestational diabetes mellitus using DIPSI criteria, a study from Pakistan. Clinical Epidemiology and Global Health, 7(2), 218-221.
https://doi.org/10.1016/j.cegh.2018.06.003
International Diabetes Federation. IDF diabetes atlas. 8th ed. Brussels, Belgium: International Diabetes Federation; 2017.
Tahir, M., Haq, N. U., Abid, A., & Zafar, A. (2020). Gestational diabetes mellitus in Pakistan: Undiagnosed threat to pregnant women. Journal of Pharmacy Practice and Community Medicine, 5(4), 80-80.
https://doi.org/10.5530/jppcm.2019.4.20
Deputy, N. P., Kim, S. Y., Conrey, E. J., & Bullard, K. M. (2018). Prevalence and changes in Preexisting diabetes and gestational diabetes among women who had a live birth — United States, 2012–2016. MMWR. Morbidity and Mortality Weekly Report, 67(43), 1201-1207.
https://doi.org/10.15585/mmwr.mm6743a2
Dickens, L. T., & Thomas, C. C. (2019). Updates in gestational diabetes prevalence, treatment, and health policy. Current diabetes reports, 19, 1-11.
https://doi.org/10.1007/s11892-019-1147-0
Zhang, C., Tobias, D. K., Chavarro, J. E., Bao, W., Wang, D., Ley, S. H., & Hu, F. B. (2014). Adherence to healthy lifestyle and risk of gestational diabetes mellitus: Prospective cohort study. BMJ, 349(sep30 1), g5450-g5450.
https://doi.org/10.1136/bmj.g5450
Rafiq, J., Karim, F., Jamal, M. M., & Chattha, M. N. (2019). Maternal and Perinatal outcome in mothers with Gestational Diabetes Mellitus in Combined Military Hospital Sialkot. Journal of The Society of Obstetricians and Gynaecologists of Pakistan, 9(2), 88-92.
https://www.jsogp.net/index.php/jsogp/article/view/210
Zhu, Y., & Zhang, C. (2016). Prevalence of gestational diabetes and risk of progression to type 2 diabetes: A global perspective. Current Diabetes Reports, 16(1).
https://doi.org/10.1007/s11892-015-0699-x
Fareed, P., Siraj, F., & Lone, K. (2017). Fetomaternal outcome in women with gestational diabetes mellitus. International Journal of Research in Medical Sciences, 5(9), 4151.
https://doi.org/10.18203/2320-6012.ijrms20174001
Aktar, Y., Hasanat, M. A., Jahan, S., Sultana, N., Hasan, M., Panthi, S., Atiqur-Rahman, M., & Fariduddin, M. (2017). Pregnancy outcome in gestational diabetes mellitus under treatment. Journal of Bioinformatics And Diabetes, 1(3), 28-34.
https://doi.org/10.14302/issn.2374-9431.jbd-17-1429
Jani, S., Parikh, P., Patel, K., Shah, A., Patel, B., & Rangrej, R. (2023). Fetomaternal outcome in patients with gestational diabetes mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 13(3), 652-6.
https://doi.org/10.5455/njppp.2023.13.01032202306022023
Patel, T. L., & Jadav, K. D. (2023). A study of feto-maternal outcome in cases of gestational diabetes mellitus. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 12(2), 377-381.
https://doi.org/10.18203/2320-1770.ijrcog20230039
Zhang, T., Tian, M., Zhang, P., Du, L., Ma, X., Zhang, Y., & Tang, Z. (2024). Risk of adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus by age: A multicentric cohort study in Hebei, China. Scientific Reports, 14(1).
https://doi.org/10.1038/s41598-023-49916-2
Fuka, F., Osuagwu, U. L., Agho, K., Gyaneshwar, R., Naidu, S., Fong, J., & Simmons, D. (2020). Factors associated with macrosomia, hypoglycaemia and low Apgar score among Fijian women with gestational diabetes mellitus. BMC Pregnancy and Childbirth, 20(1).
https://doi.org/10.1186/s12884-020-2821-6
Buchanan, T. A., & Xiang, A. H. (2005). Gestational diabetes mellitus. Journal of Clinical Investigation, 115(3), 485-491.
https://doi.org/10.1172/jci200524531
Hod, M., Kapur, A., Sacks, D. A., Hadar, E., Agarwal, M., Di Renzo, G. C., Roura, L. C., McIntyre, H. D., Morris, J. L., & Divakar, H. (2015). The international Federation of gynecology and obstetrics (FIGO) initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care#. International Journal of Gynecology & Obstetrics, 131, S173.
https://doi.org/10.1016/s0020-7292(15)30007-2
Metzger BE, Lowe LP, Dyer AR, et al. (2018). Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 358(19), 1991-2002.
https://doi.org/10.1056/nejmoa0707943
Yogev Y, Langer O. Pregnancy outcome in women with pregestational diabetes mellitus. Obstet Gynecol Clin North Am. 2021;34(2):225-36.
P Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018). The pathophysiology of gestational diabetes mellitus. International Journal of Molecular Sciences, 19(11), 3342.
https://doi.org/10.3390/ijms19113342
Mitanchez, D. (2010). Foetal and neonatal complications in gestational diabetes: Perinatal mortality, congenital malformations, macrosomia, shoulder dystocia, birth injuries, neonatal complications. Diabetes & Metabolism, 36(6), 617-627.
https://doi.org/10.1016/j.diabet.2010.11.013
Reece, E. A., Leguizamón, G., & Wiznitzer, A. (2009). Gestational diabetes: The need for a common ground. The Lancet, 373(9677), 1789-1797.
https://doi.org/10.1016/s0140-6736(09)60515-8
Catalano, P. M., McIntyre, H. D., Cruickshank, J. K., McCance, D. R., Dyer, A. R., Metzger, B. E., Lowe, L. P., Trimble, E. R., Coustan, D. R., Hadden, D. R., Persson, B., Hod, M., & Oats, J. J. (2012). The hyperglycemia and adverse pregnancy outcome study. Diabetes Care, 35(4), 780-786.
https://doi.org/10.2337/dc11-1790
Rizzo, T., Metzger, B. E., Burns, W. J., & Burns, K. (1991). Correlations between Antepartum maternal metabolism and intelligence of offspring. New England Journal of Medicine, 325(13), 911-916.
https://doi.org/10.1056/nejm199109263251303
Maayan-Metzger A, Schushan-Eisen I, Todris L, et al. (2019). Short- and long-term complications among infants born small-for-gestational-age. Arch Gynecol Obstet, 280(3), 485-91.
Correa, A., Gilboa, S., Besser, L., Botto, L., Moore, C., Hobbs, C., Cleves, M., Riehle-Colarusso, T., Waller, D., & Reece, E. (2009). Diabetes mellitus and birth defects. Obstetric Anesthesia Digest, 29(1), 40-41.
https://doi.org/10.1097/01.aoa.0000344708.41667.f0
Behrman, R. E., & Butler, A. S. (2007). Preterm birth: causes, consequences, and prevention. National Academies Press; 2017.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research

This work is licensed under a Creative Commons Attribution 4.0 International License.
