Health Benefits, Associated Disorders and Influencing Factors of Gut Microbiota: A Comprehensive Review

Zeeshan Ali; Sumaira Saeed; Bushra Jabeen Mehdi; Hafsa Ahmed; Syed Ashiq Hussain; Naila Bashir; Javaria Ashfaq; Muhammad Muzamil; Muhammad Aftab Zahoor; Muhammad Asad Ali Khan; Noor-Ul-Huda

doi:10.70749/ijbr.v3i6.1138

Authors

Zeeshan Ali Department of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan.
Sumaira Saeed Department of Precision Medicine, University of Campania "Luigi Vanvitelli" 80138 Naples, Italy.
Bushra Jabeen Mehdi Biomedical Engineering Department, Sir Syed University of Engineering and Technology, Karachi.
Hafsa Ahmed Biomedical Engineering Department, Sir Syed University of Engineering and Technology, Karachi.
Syed Ashiq Hussain National Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilizations, Anhui Agricultural University, Hefei 230036, China
Naila Bashir Department of Food Science and Technology, The University of Haripur, Pakistan.
Javaria Ashfaq Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Pakistan.
Muhammad Muzamil Department of Food Science and Technology, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Muhammad Aftab Zahoor Department of Food Science and Technology, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Muhammad Asad Ali Khan Department of Food Science and Technology, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Noor-Ul-Huda Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i6.1138

Keywords:

Gut microbiota, Human health, Disease, Factors, Metabolic process

Abstract

The gut microbiota considered as the diverse community of the microorganisms that found within the gastrointestinal tract. It plays a significant role and provides health benefits to the body in various processes including mental, digestive and metabolic health. This review article highlighted and elaborated the gut microbiota composition, factors affecting on the gut microbiota essential for the metabolic health of body and its brief beneficial role for the human body and also discussed the diseases associated with the gut microbiota in detail. It is also considered that gut microbiome plays a beneficial role in maintaining and improving the overall health of body by employing various mechanisms such as synthesis of vitamins, development and production of short chain fatty acids (i.e., SCFA) and breakdown of the carbohydrates considered as complex. These all factors exhibit healthy role maintenance and regulation of gut associated barriers, improving immunity and fat metabolism system. The disturbance in microbial community of gut leads to gastrointestinal, metabolic and neurological disorders. Different factors such as life style, diet and exercise significantly shapes the gut microbiota which helps in designing personalized therapeutic strategies to prevent life threatening diseases. This review depicts detailed literature on the relation of gut microbiome with the body health.

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