Evaluation of Hyperlipidemia and Elevated Ischemia Modified Albumin (IMA) as Major Risk Factors for Acute Coronary Syndrome (ACS) in Tuberculosis Patients: A Cross-Sectional Study at LUMHS


  • Dr Rabia Uqailia Lecturer Physiology Jinnah Sindh Medical University (JSMU) Karachi, Sindh-Pakistan
  • Prof Salma Farrukh Memonb Professor of Physiology Liaquat Universtiy of Medical and health Sciences, Jamshoro, Sindh-Pakistan
  • Dr Arsalan Ahmed Uqaili Assistant Professor Department of Physiology, Liaquat University of Medical and Health Sciences, Jamshoro Sindh-Pakistan
  • Dr Padma Rathored Assistant Professor, Physiology deptt SMC; JSMU
  • Dr Noor un Ninae Assistant Professor , incharge Physilology department M.Phil in Physiology Jinnah Sindh Medical University Karachi
  • Tallat Naz Instructor, Department of Physiology, M.Phil in Physiology Jinnah Sindh Medical University Karachi


Tuberculosis, Hyperlipidemia, Ischemia Modified Albumin, Acute Coronary Syndrome, Cross-Sectional Study, Risk Factors


Background: Tuberculosis (TB) patients may have an increased risk of Acute Coronary Syndrome (ACS) due to associated hyperlipidemia and elevated Ischemia Modified Albumin (IMA) levels. However, the extent of this association has not been thoroughly evaluated.

Objective: To assess the significance of hyperlipidemia and elevated IMA levels as risk factors for ACS among TB patients.

Methods: A cross-sectional study was conducted at Liaquat University of Medical & Health Sciences (LUMHS), involving 200 participants diagnosed with TB. Non-convenience sampling was used to ensure a representative sample. Participants underwent a comprehensive physical exam and blood sampling for lipid profile and IMA concentration analysis.

Results: The study found a wide range of BMI, blood pressure, and cholesterol levels among participants. IMA levels were relatively stable across the cohort. A significant positive correlation between IMA levels and BMI (p<0.05) was identified, suggesting that higher BMI is associated with increased IMA levels. Participants were categorized into three groups based on IMA levels, revealing that higher IMA levels correlate with poorer lipid profiles and more severe TB status.

Conclusion: Elevated IMA levels and hyperlipidemia are associated with an increased risk of ACS in TB patients. This association underscores the need for careful cardiovascular risk assessment and management in this population.