Biological Investigation of Aqueous Extract of Funnel Seeds to Check its Therapeutic Effects in the Management of Polycystic Ovarian Syndrome in Induced PCOS Female Albino Rats
DOI:
https://doi.org/10.70749/ijbr.v2i02.253Keywords:
Funnel Seeds, Ovarian Syndrome (PCOS), Follicle Stimulating Hormone, Luteinizing HormoneAbstract
About every one out of nine women around the globe is living with polycystic ovarian syndrome. Polycystic ovarian syndrome is characterized by increased male hormone (androgen) in female body that results in delayed ovulation by unbalancing follicle stimulating hormone, luteinizing hormone, testosterone, and insulin levels. Other associated signs are increased insulin levels due to elevated androgens, weight gain, male pattern hair growth, and depression. Funnel seed is a wonder in regulating the imbalanced reproductive hormones. The purpose of Current study was to evaluate the hormone regulating properties by using funnel seed as source element. For this purpose, 14 female albino rats with induced polycystic ovarian syndrome were divided into two group. Treatment group was given funnel seed extract in dose of 50mg/kg of the body weight for sixty days. Levels of follicle stimulating hormone, luteinizing hormone, testosterone and insulin levels were measured and compared in blood samples on 0th day and 60th day in study groups. Insulin and testosterone levels were significantly (p<0.05) lower in the treatment group, whereas ovulating hormones, such as follicle stimulating hormone and luteinizing hormone, were significantly (p<0.05) higher.
References
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007). Polycystic ovary syndrome. The Lancet, 370(9588), 685–697. https://doi.org/10.1016/s0140-6736(07)61345-2
Guzick, D. S. (2004). Polycystic Ovary Syndrome. Obstetrics & Gynecology, 103(1), 181–193. https://doi.org/10.1097/01.aog.0000104485.44999.c6
Ommen, S. R., Mital, S., Burke, M. A., Day, S. M., Deswal, A., Elliott, P., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P., Kimmelstiel, C., Kittleson, M., Link, M. S., Maron, M. S., Martinez, M. W., Miyake, C. Y., Schaff, H. V., Semsarian, C., & Sorajja, P. (2020). 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy. Circulation, 142(25). https://doi.org/10.1161/cir.0000000000000937
Wolf, A. M., Fontham, E. T., Church, T. R., Flowers, C. R., Guerra, C. E., LaMonte, S. J., ... & Smith, R. A. (2018). Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society. CA: a cancer journal for clinicians, 68(4), 250-281. https://doi.org/10.3322/caac.21457
Azziz, R. (2018). Polycystic ovary syndrome. Obstetrics & Gynecology, 132(2), 321-336. https://doi.org/10.1097/aog.0000000000002698
Khani, S., Abdollahi, M., Khalaj, A., Heidari, H., & Zohali, S. (2021). The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study. International Journal of Reproductive BioMedicine, 19(3), 271. https://doi.org/10.18502/ijrm.v19i3.8575
Ali, B. H., & Blunden, G. (2003). Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research: An international journal devoted to pharmacological and toxicological evaluation of natural product derivatives, 17(4), 299-305. https://doi.org/10.1002/ptr.1309
Kalleli, F., Bettaieb Rebey, I., Wannes, W. A., Boughalleb, F., Hammami, M., Saidani Tounsi, M., & M'hamdi, M. (2019). Chemical composition and antioxidant potential of essential oil and methanol extract from Tunisian and French fennel (Foeniculum vulgare Mill.) seeds. Journal of food biochemistry, 43(8), e12935. https://doi.org/10.1111/jfbc.12935
Ahmad, B. S., Talou, T., Saad, Z., Hijazi, A., Cerny, M., Kanaan, H., ... & Merah, O. (2018). Fennel oil and by-products seed characterization and their potential applications. Industrial crops and products, 111, 92-98. https://doi.org/10.1016/j.indcrop.2017.10.008
Hossain, M. M., Cao, M., Wang, Q., Kim, J. Y., Schellander, K., Tesfaye, D., & Tsang, B. K. (2013). Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model. Journal of ovarian research, 6(1), 1-11. https://link.springer.com/article/10.1186/1757-2215-6-36
Damjanović, B., Lepojević, Ž., Živković, V., & Tolić, A. (2005). Extraction of fennel (Foeniculum vulgare Mill.) seeds with supercritical CO2: Comparison with hydrodistillation. Food Chemistry, 92(1), 143-149. https://doi.org/10.1016/j.foodchem.2004.07.019
Bhide, A., Shah, P. S., & Acharya, G. (2018). A simplified guide to randomized controlled trials. Acta obstetricia et gynecologica Scandinavica, 97(4), 380-387. https://doi.org/10.1111/aogs.13309
Ha, K. Y., Carragee, E., Cheng, I., Kwon, S. E., & Kim, Y. H. (2011). Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells. Journal of Korean medical science, 26(3), 404-411. https://doi.org/10.3346/jkms.2011.26.3.404
D’Agostino, R. B. (2017). Tests for the normal distribution. In Goodness-of-fit-techniques (pp. 367-420). Routledge. https://www.taylorfrancis.com/chapters/edit/10.1201/9780203753064-9/tests-normal-distribution-ralph-agostino
Moradi, S. Z., Momtaz, S., Bayrami, Z., Farzaei, M. H., & Abdollahi, M. (2020). Nanoformulations of herbal extracts in treatment of neurodegenerative disorders. Frontiers in bioengineering and biotechnology, 8, 238. https://doi.org/10.3389/fbioe.2020.00238
Khanage, S. G., Subhash, T. Y., & Bhaiyyasaheb, I. R. (2019). Herbal drugs for the treatment of polycystic ovary syndrome (PCOS) and its complications. Pharm. Res, 2(1), 5-13
. Poojar, B., Ommurugan, B., Adiga, S., & Thomas, H. (2017). Evaluation of antiurolithiatic property of ethanolic extract of fennel seeds in male wistar albino rats. Asian Journal of Pharmaceutical and Clinical Research, 10(8). http://dx.doi.org/10.22159/ajpcr.2017.v10i8.18923
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.