A Comparative Study to Evaluate the Efficacy of Skin Microneedling and Platelet Rich Plasma (PRP) Combination Versus Skin Micro Needling Alone for the Treatment of Atrophic Facial Acne Scars Using Goodman and Baron’s Grading
DOI:
https://doi.org/10.70749/ijbr.v2i02.218Keywords:
Atrophic Facial Acne Scars, Micro-Needling, Platelet Rich PlasmaAbstract
BACKGROUNDOne unfortunate and permanent effect of acne vulgaris is atrophic scarring. The ailment is rather common and greatly affects the quality of life of the person. Tests of micro needling have been conducted both as a stand-alone therapy and in combination with chemical peeling, platelet-rich plasma, radiofrequency, subcision, and lasers.
OBJECTIVETo assess the effectiveness of a combined treatment using skin micro needling and platelet rich plasma (PRP) compared to skin micro needling alone in treating atrophic facial acne scars.
METHODOLOGY
Randomized control trial (RCT) and comparative study were conducted in department of Dermatology, MTI/Lady Reading Hospital, Peshawar, for the duration of one year. Out of 100 patients 50 were included in each group in the study. Group-A was treated with skin micro needling and PRP while Group-B with skin micro needling alone for the treatment of atrophic facial acne scars.
RESULTSMean age of the patients of group-A was 28.0±6.2 and group-B was 29.4±5.2 years. Females were predominant in both groups. Mean duration of symptoms in group-A was 9.0±8.5 month and in group-B 10.9±8.5 months. Combined therapy with micro needling and PRP reported 82% efficacy while skin micro needling alone showed 62% efficacy for the management of atrophic scars from face acne (p=0.026).
CONCLUSIONIn conclusion, combination of skin micro needling and platelet rich plasma (PRP) is more effective than needling alone for the treatment of atrophic facial acne scars.
References
Herane MI, Ando I. Acne in infancy and acne genetics. Dermatology. 2003;206(1):24-8.
Badheka AD et al. A study of efficacy of subcision, micro-needling and carbon dioxide fractional laser for treatment of acne scars. lnt J Res Med Sci 2016;4(7):2623-9.
Wolfram D, Tzankov A, Pülzl P, Piza-Katzer H. Hypertrophic scars and keloids--a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg. 2009;35(2):171-81.
Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol. 2001;45(1):109-17.
Fife D. Practical evaluation and management of atrophic acne scars: tips for the general dermatologist. J Clin Aesthet Dermatol. 2011;4 (8):50-7.
Gozali MV. Zhou B. Effective treatments of atrophic acne scars. J Clin Aesthet Dermatol 2015;8(5):33 - 40.
El-Domyati M, Barakat M, Awad S, Medhat W, El- Fakahany H, Farag H. Microneedling Therapy for Atrophic Acne Scars: An Objective Evaluation. J Clin Aesthet Dermatol. 2015;8(7):36-42.
Gulanikar AD, Vidholkar R. Efficacy of platelet-rich plasma in acne scars. Clin Dermatol 2019;3(2): 109-14.
Fernandes D, Signorini M. Combating photoaging with percutaneous collagen induction. Clin Dermatol. 2008;26(2):192-9.
Asif M, Kanodia S, Singh K. Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study. J Cosmet Dermatol. 2016;15(4):434-43.
Saurabh Sharma, Tanreet Kaur, Roopam Bassi. A split face comparative study to evaluate the efficacy of skin microneedling and platelet rich plasma (PRP) combination versus skin microneedling alone for treatment of post acne scars. J Pak Associat Dermatol 2020; 30(3): 449-455.
Layton AM, Henderson CA, Cunliffe WJ. A clinical evaluation of acne scarring and its incidence. Clin Exp Dermatol. 1994;19:303–8.
Poli F, Dreno B, Verschoore M. An epidemiological study of acne in female adults: Results of a survey conducted in France. J Eur Acad Dermatol Venereol. 2001;15:541–5.
Tan J, Kang S, Leyden J. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the USA. J Drugs Dermatol. 2017;16:97–102.
Camirand A, Doucet J. Needle dermabrasion. Aesthetic Plast Surg. 1997;21:48–51.
Orentreich DS, Orentreich N. Subcutaneous incisionless (subcision) surgery for the correction of depressed scars and wrinkles. Dermatol Surg. 1995;21:543–9.
Fabbrocini G, Fardella N, Monfrecola A, Proietti I, Innocenzi D. Acne scarring treatment using skin needling. Clin Exp Dermatol. 2009;34:874–9.
Sclafani AP. Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial Plast Surg. 2009;25:270–6.
Dogra S, Yadav S, Sarangal R. Microneedling for acne scars in asian skin type: An effective low cost treatment modality. J Cosmet Dermatol. 2014;13: 180–7.
Majid I. Microneedling therapy in atrophic facial scars: An objective assessment. J Cutan Aesthet Surg. 2009;2:26–30.
Sharad J. Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin. J Cosmet Dermatol. 2011;10:317–23.
Gawdat HI, Hegazy RA, Fawzy MM, Fathy M. Autologous platelet rich plasma: Topical versus intradermal after fractional ablative carbon dioxide. laser treatment of atrophic acne scars. Dermatol Surg. 2014;40:152–61.
Ibrahim ZA, El-Ashmawy AA, Shora OA. Therapeutic effect of microneedling and autologous platelet-rich plasma in the treatment of atrophic scars: A randomized study. J Cosmet Dermatol. 2017;16:388–99.
Fabbrocini G, Vita VD, Pastore F, Panariello L, Fardella N, Sepulveres R, et al. Combined use of skin needling and platelet-rich plasma in acne scarring treatment. J Cosmet Dermatol. 2011; 24:177–83.
Porwal S, Chahar YS, Singh PK. A comparative study of combined dermaroller and platelet-rich plasma versus dermaroller alone in acne scars and assessment of quality of life before and after treatment. Indian J Dermatol. 2018;63:403–8.
Kang C, Lu D. Combined effect of microneedling and platelet-rich plasma for the treatment of acne scars: a meta-analysis. Front Med (Lausanne). 2022;8:788754.
Fabbrocini G, De Vita V and Pastore F. The use of skin needling for eutectic mixture of local anesthetics delivery. Dermat Ther. 2011;2(7):188- 92.
Fernandes D. Minimally invasive percutaneous collagen induction. Oral Maxillofacial Surg Clin N Am. 2005;11(3):51-63.
Majid M. Microneedling therapy in atrophic facial scars: An objective assessment. J Cutan Aesthet Surg [serial online] 2009;2:26-30.
Gupta M, Barman KD, Sarkar R. A comparative study of microneedling alone versus along with platelet-rich plasma in acne scars. J Cutan Aesthet Surg. 2021;14(1):64–71.
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