A Comparative Study on Absorbable and Non-Absorbable Suture Materials for the Closure of Skin in Rabbit Model

Authors

  • Tamseel Saleem Sindh Agriculture University, Tandojam, Pakistan
  • Allah Bux Kachiwal Sindh Agriculture University Tandojam, Pakistan
  • Aliza Memon Sindh Agriculture University, Tandojam, Pakistan
  • Ahsan Memon Sindh Agriculture University, Tandojam, Pakistan
  • Fiza Memon Sindh Agriculture University, Tandojam, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v2i02.127

Keywords:

Absorbable Sutures, Non-Absorbable Sutures, Wound Closure, Rabbit Model, Wound Healing

Abstract

 Skin closure is a critical component of surgical procedures, and the selection of suture material has a significant impact on wound healing outcomes. This investigation aims to compare the effectiveness of absorbable and non-absorbable sutures for skin closure in rabbits. An experimental study was conducted on thirty (n=30) male rabbits aged 9.78+0.46 weeks and with an average weight of 1186.94+69.93 gms. Rabbits were divided into two groups, with one receiving absorbable sutures while the other received non-absorbable sutures. Wound healing parameters such as wound closure time, tensile strength, tissue reaction, and histological evaluation were evaluated over a specified period. Our findings suggest that both types of suture materials are effective in closing skin wounds in rabbits. However, absorbable sutures exhibited faster wound closure times and less tissue reaction compared to non-absorbable sutures. Conversely, non-absorbable sutures demonstrated higher tensile strength and better histological evaluations at the wound site. The results indicated significantly better wound healing with non-absorbable suture material than with absorbable suture material; indeed, there was an outstandingly high (++++) wound healing score when using non-absorbable suture material compared to that obtained from using absorbables. Moreover, rabbits recovered excellently from wounds treated with non-absorbables; thus demonstrating that choosing a specific type of suture material should be based on individual patient factors and requirements for each surgical procedure. Further studies are required to confirm these findings across larger animal models or human patients conclusively. In conclusion, it is evident that opting for non-absorbent materials results in expedited skin wound healing with superior outcomes when compared to their absorbent counterparts.

References

Baig, M., Yousaf, I., Galbraith, J., & Din, R. (2017). Absorbable Polydioxanone (PDS) suture provides fewer wound complications than polyester (ethibond) suture in acute Tendo-Achilles rupture repair. PubMed, 110(5), 566–566. http://hdl.handle.net/10147/622537

Bonham, J. (2011). Comparison of suture types in the closure of scalp wounds. Emergency Nurse, 19(3), 34–39. https://doi.org/10.7748/en2011.06.19.3.34.c8557

Broughton, G., & Rohrich, R. J. (2005). Wounds and scars. SRPS, 10(7), 2.

Carr, B. J., Ochoa, L., Rankin, D., & Owens, B. D. (2009). Biologic Response to Orthopedic Sutures: A Histologic Study in a Rabbit Model. Orthopedics. https://doi.org/10.3928/01477447-20090922-11

Dennis, C., Sethu, S., Nayak, S., Mohan, L., Morsi, Y. Y., & Manivasagam, G. (2016). Suture materials - Current and emerging trends. Journal of Biomedical Materials Research Part A, 104(6), 1544–1559. https://doi.org/10.1002/jbm.a.35683

DUNLAP, W. A., PURNELL, W. D., Hill, C., & McPHERSON, S. D. (1976). A New Synthetic Absorbable Suture for Ophthalmic Surgery. Southern Medical Journal, 69(5), 588–592. https://doi.org/10.1097/00007611-197605000-00031

Esenyel, C. Z. (2009). Evaluation of soft tissue reactions to three nonabsorbable suture materials in a rabbit model. Acta Orthopaedica et Traumatologica Turcica, 43(4), 366–372. https://doi.org/10.3944/aott.2009.366

Flecknell, P. A. (1987). Laboratory animal anaesthesia : an introduction for research workers and technicians. In Academic Press eBooks. Academic Press.

Jenkins, E. D., Melman, L., Desai, S., Brown, S. R., Frisella, M. M., Deeken, C. R., & Matthews, B. D. (2010). Evaluation of intraperitoneal placement of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant in a New Zealand white rabbit model. Surgical Endoscopy and Other Interventional Techniques, 25(2), 604–612. https://doi.org/10.1007/s00464-010-1230-8

Kaminski, J. M., Katz, A. R., & Woodward, S. C. (1978). Urinary bladder calculus formation on sutures in rabbits, cats and dogs. Surgery, Gynecology & Obstetrics, 146(3), 353-357.

Khan, I. (2021). Comparative study on semen quality, gonadal hormone level, morphometry and ultrasonographic measurement of testicles and epididymis in vasectomized rabbit.M.Phil Thesis, Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan.

Kocaoglu, B., Ulku, T. K., Gereli, A., Karahan, M., & Turkmen, M. (2015). Evaluation of Absorbable and Nonabsorbable Sutures for Repair of Achilles Tendon Rupture With a Suture-Guiding Device. Foot & Ankle International, 36(6), 691–695. https://doi.org/10.1177/1071100714568868

Kreszinger, M., Kos, J., Snježana Vuković, Vnuk, D., Dražen Matičić, Pirkić, B., Stejskal, M., Marko Pećin, Ozren Smolec, Petar Kostešić, & Abaffy, M. (2011). Influence of suture material on biomechanical and histological indicators of Achilles tendon heeling in rabbits. Veterinarski Arhiv, 81(2), 223–233.

Kudur, M. H., Pai, S. B., Sripathi, H., & Prabhu, S. (2009). Sutures and suturing techniques in skin closure. Indian journal of dermatology, venereology and leprology, 75, 425. https://ijdvl.com/content/126/2009/75/4/Images/ijdvl_2009_75_4_425_53155.pdf

Lipman, N. S., Marini, R. P., & Erdman, S. E. (1990). A comparison of ketamine/xylazine and ketamine/xylazine/acepromazine anesthesia in the rabbit. Laboratory animal science, 40(4), 395-398.

Luck, R. P., Flood, R., Eyal, D., Saludades, J., Hayes, C., & Gaughan, J. (2008). Cosmetic Outcomes of Absorbable Versus Nonabsorbable Sutures in Pediatric Facial Lacerations. Pediatric Emergency Care, 24(3), 137–142. https://doi.org/10.1097/pec.0b013e3181666f87

Morris, M. C., Baquero, A., Redovan, E., Mahoney, E., & Bannett, A. D. (1986). Urolithiasis on absorbable and non-absorbable suture materials in the rabbit bladder. The Journal of Urology, 135(3), 602–603. https://doi.org/10.1016/s0022-5347(17)45758-2

Oni, G., Brown, S. A., & Kenkel, J. M. (2012). A Comparison between Barbed and Nonbarbed Absorbable Suture for Fascial Closure in a Porcine Model. Plastic and Reconstructive Surgery, 130(4), 535e540e. https://doi.org/10.1097/prs.0b013e318262f0f6

Papazoglou, L. G., Tsioli, V., Papaioannou, N., Georgiadis, M., Savvas, I., Prassinos, N., ... & Zavros, N. (2010). Comparison of absorbable and nonabsorbable sutures for intradermal skin closure in cats. The Canadian Veterinary Journal, 51(7), 770.

Parell, G. J., & Becker, G. D. (2003). Comparison of Absorbable With Nonabsorbable Sutures in Closure of Facial Skin Wounds. Archives of Facial Plastic Surgery, 5(6), 488. https://doi.org/10.1001/archfaci.5.6.488

Park, J. H., Chun, D.-I., Lee, S. H., & Cho, J. H. (2017). A Comparative Evaluation of Absorbable and Nonabsorbable Sutures for Open Repair of Achilles Tendon Rupture: A Pilot Study. Korean Journal of Physical Anthropology, 30(2), 39. https://doi.org/10.11637/kjpa.2017.30.2.39

Satheshkumar, Soundara Pandian,. (2005). Ketamine - Xylazine anaesthesia in rabbits. Indian Veterinary Journal. 82. 388-389.

Scheidel, P. H., Wallwiener, D. R., Holländer, D., & Hepp, H. K. (1986). Absorbable or Nonabsorbable Suture Material for Microsurgical Tubal Anastomosis: Randomized Experimental Study on Rabbits. Gynecologic and obstetric investigation, 21(2), 96-102. https://doi.org/10.1159/000298935

Scheidel, P. H., Wallwiener, D. R., Holländer, D., & Hepp, H. K. (1986). Absorbable or Nonabsorbable Suture Material for Microsurgical Tubal Anastomosis. Gynecologic and Obstetric Investigation, 21(2), 96–102. https://doi.org/10.1159/000298935

Soomro, R. N. (2022). Studies on effect of tranexamic acid on bleeding time, clotting time and platelets count in experimentally induced hemorrhagic rabbits. Thesis, Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan.

Sparmann M. (1995). [Value of various suture materials for defect reconstruction of peripheral nerves]. PubMed, 27(6), 322–328.

Taha, M. O., De Rosa, K., & Fagundes, D. J. (2006). The role of biological adhesive and suture material on rabbit hepatic injury. Acta Cirurgica Brasileira, 21(5), 310–314. https://doi.org/10.1590/s0102-86502006000500007

Vitello, D. J., Ripper, R. M., Fettiplace, M. R., Weinberg, G. L., & Vitello, J. M. (2015). Blood Density Is Nearly Equal to Water Density: A Validation Study of the Gravimetric Method of Measuring Intraoperative Blood Loss. Journal of Veterinary Medicine, 2015, 1–4. https://doi.org/10.1155/2015/152730

Wada, A., Kubota, H., Akiyama, T., Hatanaka, H., Miura, H., & Iwamoto, Y. (2001). Effect of absorbable polydioxanone flexor tendon repair and restricted active mobilization in a canine model. The Journal of Hand Surgery, 26(3), 398–406. https://doi.org/10.1053/jhsu.2001.24134

Wichelhaus, D. A., Beyersdoerfer, S. T., Gierer, P., Vollmar, B., & Mittlmeier, T. (2016). The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model. Arch. Orthop. Trauma Surg, 136(7), 1021–1029. https://doi.org/10.1007/s00402-016-2472-2

Yang, C. S., Chen, C. Y., Chiang, C. H., Tung, C. L., Chen, M. Y., Yeh, C. H., ... & Yeh, M. L. (2011). The effect of suture size on skin wound healing strength in rats. Journal of Medical and Biological Engineering, 31(5), 339-343.

Yildirim, Y., Saygi, B., Kara, H., Kabukoglu, C., & Esemenli, T. (2006). Tendon holding capacities of the suture materials used in repairing Achilles tendon rupture. Acta Orthopaedica et Traumatologica Turcica, 40(2), 164-168.

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Published

2024-11-12

How to Cite

Saleem, T., Kachiwal, A. B., Memon, A., Memon, A., & Memon, F. (2024). A Comparative Study on Absorbable and Non-Absorbable Suture Materials for the Closure of Skin in Rabbit Model. Indus Journal of Bioscience Research, 2(02), 302–310. https://doi.org/10.70749/ijbr.v2i02.127