Derangement of Serum Electrolytes in Term Infants with Perinatal Asphyxia Presenting to NICU of Bacha Khan Medical Complex Swabi
DOI:
https://doi.org/10.70749/ijbr.v2i02.105Keywords:
Perinatal asphyxia, serum electrolytes, neonates, NICU, hyponatremia, hypocalcemia, electrolyte imbalanceAbstract
The Perinatal asphyxia remnants the critical condition connected with the important morbidity and mortality in the infants, particularly in the resource-limited settings. So, this cross-sectional study aimed to consider prevalence of the serum electrolyte confusions in the term infants diagnosed with the perinatal asphyxia acknowledged to Neonatal Intensive Care Unit the (NICU) at Bacha Khan Medical Complex Swabi. The total of 100 term infants with an Apgar score of less than 7 at 5 minutes or the demanding resuscitation at the birth was included. The Electrolyte levels were measured for the sodium, potassium, calcium, and the chloride, and derangements were identified based on the established reference ranges. The Results indicated that 51% of the infants experienced hyponatremia, although 36% had hypokalemia and 35% hypocalcemia. The Statistically significant associations were found between the electrolyte abnormalities and the poorer clinical outcomes, with the infants exhibiting derangements requiring longer the NICU stays (mean 12.5 ± 4.6 days vs. 7.2 ± 3.1 days) and the higher incidence of the ventilatory support needs (35% vs. 10%). So these findings underscore critical importance of early recognition and the management of the electrolyte imbalances in the asphyxiated infants to improve the clinical outcomes and optimize neonatal care practices. For Further research is warranted to explore long-term implications of these disturbances and develop standardized management protocols in the NICUs.
References
Alsayed, S. E. (2024). Updates in Oral Management of Dehydration and Electrolyte Disturbance in Infants and Children: A Systematic Review. Saudi Journal of Medical and Pharmaceutical Sciences, 10(02), 110–116. https://doi.org/10.36348/sjmps.2024.v10i02.008
Cannavò, L., Perrone, S., & Gitto, E. (2023). Brain-Oriented Strategies for Neuroprotection of Asphyxiated Newborns in the First Hours of Life. Pediatric Neurology, 143, 44–49. https://doi.org/10.1016/j.pediatrneurol.2023.02.015
Chukwu, J., & Molloy, E. J. (2020). Fluid and Electrolyte Balance in Infants and Children. Springer EBooks, 245–261. https://doi.org/10.1007/978-3-662-43588-5_16
Iacobelli, S., & Guignard, J.-P. (2020). Renal aspects of metabolic acid-base disorders in neonates. Pediatric Nephrology (Berlin, Germany), 35(2), 221–228. https://doi.org/10.1007/s00467-018-4142-9
Jovandaric, M. Z. (2024). Perinatal Asphyxia, Hypoxia, Ischemia, and the Newborn. In Asphyxia in Neonates (pp. 1-16). CRC Press.
Locci, E., Bazzano, G., Demontis, R., Chighine, A., Fanos, V., & d’Aloja, E. (2020). Exploring Perinatal Asphyxia by Metabolomics. Metabolites, 10(4), 141. https://doi.org/10.3390/metabo10040141
Moss, C. R. (2022). Fluid and Electrolyte Management in the Neonate. Neonatal Network, 41(4), 211–218. https://doi.org/10.1891/nn-2021-0021
Nagalo, K., Toguyéni, L., Douamba, S., Konaté, B., Porgo, S., Bélemviré, A., ... & Yé, D. (2024). Perinatal Asphyxia in a Hospital Setting in a Developing Country. Renal failure, 90(246), 82-0.
Núñez, A. R., Benavente, I., Blanco, D., Boix, H., Cabañas, F., Chaffanel, M., Belén Fernández-Colomer, José Ramón Fernández-Lorenzo, Loureiro, B., Moral, M., Pavón, A., Inés Tofe, Valverde, E., & Vento, M. (2018). Oxidative stress in perinatal asphyxia and hypoxic-ischaemic encephalopathy. Anales de Pediatría (English Edition), 88(4), 228.e1–228.e9. https://doi.org/10.1016/j.anpede.2017.05.004
Saha, U. (2023). General Anatomical and Physiological Considerations in the Newborn and Neonates. 137–204. https://doi.org/10.1007/978-981-19-5458-0_10
Seid, M. A., Adella, G. A., Kassie, G. A., Mengstie, M. A., Dejenie, T. A., Melkamu Aderajew Zemene, Anteneh Mengist Dessie, Kebede, Y. S., Berihun Bantie, Wubet Alebachew Bayih, Abebe, E. C., Molalegn Mesele Gesese, Feleke, S. F., & Denekew Tenaw Anley. (2023). Serum electrolyte imbalance in severely malnourished children at hospitals in North-central Ethiopia. https://doi.org/10.21203/rs.3.rs-3008642/v1
Tumukunde, J., & Stickney, C. (2023). Paediatric critical care in resource-limited settings: An overview. Update in Anaesthesia, 37.
Vega-del-Val, C., Arnaez, J., Ochoa-Sangrador, C., Garrido-Barbero, M., & García-Alix, A. (2024). Incidence of encephalopathy and comorbidity in infants with perinatal asphyxia: a comparative prospective cohort study. Frontiers in Pediatrics, 12. https://doi.org/10.3389/fped.2024.1363576
Whitmore, S. P., & Gunnerson, K. J. (2020). Acid-Base and Electrolyte Disorders in Emergency Critical Care. Emergency Department Critical Care, 301–329. https://doi.org/10.1007/978-3-030-28794-8_18
Yu, Y., Gao, J., Liu, J., Tang, Y., Zhong, M., He, J., Liao, S., Wang, X., Liu, X., Cao, Y., Liu, C., & Sun, J. (2022). Perinatal maternal characteristics predict a high risk of neonatal asphyxia: A multi-center retrospective cohort study in China. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.944272
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
